一：复合SERS基底的设计与制备

利用多孔材料包括MOFs/COFs/HOFs、PS、SiO2作为纳米载体结合贵金属纳米颗粒构建高效的SERS基底

二：生物传感器的构建与设计

利用DNA适体或者抗体构建超灵敏SERS与电化学传感器用于污染物或者生物标志物的检测

三：多重DNA放大技术的设计与应用

设计目标物诱导多重DNA放大技术以及构建DNA框架材料

项目：食品及农产品中危害残留物快速检测技术四川省青年科技创新研究团队-四川省科技计划项目专项资金

学术论文：

[1] Runzi Zhang, Shunbi Xie*, Xiaoyu Yang, Yao Liu, Yi He*. Efficient SERS Substrate HOF@Au in Conjunction with DNAzyme-Mediated DNA Walker as a Signal Amplifier for the Ultrasensitive Detection of Lomefloxacin. Analytical Chemistry, 2025, 97, 3180−3189.（中科院一区，IF = 6.7，自然指数期刊）

[2] Runzi Zhang, Shunbi Xie*, Xiaoyu Yang, Yao Liu, Xiaojun Luo*, Yi He*. Uniform 3D SERS substrate SiO₂@AuAg collaborate with target-mediated DNA network structure as a signal amplifier for ultrasensitive detection of miRNA-21. Biosensors and Bioelectronics, 2025, 288, 117777.（中科院一区，IF = 10.5）

[3] Runzi Zhang, Shunbi Xie*, Xiaoyu Yang, Yao Liu, Ke Lei, Mengjun Wang*, Yi He*. Au-Ag alloy nanourchins as a highly efficient SERS tag synergistically with MOF@Au for the ultrasensitive detection of oxytetracycline. Journal of Colloid and Interface Science, 2025, 695, 137840.（中科院一区，IF = 9.7）

[4] Yi He*, Runzi Zhang, Shunbi Xie*, Xiaoyu Yang, Yao Liu. An intelligent hydrogel detection platform based on colorimetric and SERS techniques for real-time and sensitive detection of kanamycin. Talanta, 2025, 294, 128246.（中科院二区，IF = 6.1）

[5] Yi He*, Runzi Zhang, Shunbi Xie*, Xiang He, Xioayu Yang, Yao Liu, Mengjun Wang*. A triple-mode strategy for ultrasensitive and accurate point-of-care detection of glyphosate based on the carved bimetallic prussian blue nanozyme and gold polyhedra. Journal of Food Composition and Analysis, 2025, 144, 107661.（中科院二区，IF = 4.6）

[6] Runzi Zhang, Shunbi Xie*, Xiaoyu Yang, Youlin Tang, Jingwen Liu, Manjun Liao, Mengjun Wang*, Yi He*. A SERS and colorimetric dual‑mode biosensor based on stimulus‑responsive DNA/MOF‑bound bimetallic nanozyme for the ultrasensitive detection of chloramphenicol in food. Microchimica Acta, 2025, 192, 62. (中科院二区，IF = 5.3，高被引)

[7] Runzi Zhang, Shunbi Xie*, Youlin Tang, Xiang He, Xiaoyu Yang, Yao Liu, Mengjun Wang*, Yi He*. Dual-catalytic hairpin amplification strategy as a highly efficient signal amplifier cooperative with COF@Au for ultrasensitive SERS detection of miRNA-21. Analytica Chimica Acta, 2025, 1369, 344361.（中科院二区，IF = 6.0）

[8] Xiaoyu Yang, Shunbi Xie*, Runzi Zhang, Yao Liu, Weifen Wu, Yi He*. An efficient SERS detection platform based on roseate petal homochiral nanogold (Au RHNs) as substrate for sensitive detection of plastics in environmental water samples. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2025, 329, 125642.（中科院二区，IF = 4.6）

[9] Yao Liu, Runzi Zhang, Xiaoyu Yang, Yi He*, Xiao Yang*. An ultrasensitive SERS biosensor based on porous ZIF-8-encapsulated silver nanoflowers coordinated with host-gest recognition amplification strategy for the detection of bisphenol S. Microchemical Journal, 2025, 215, 114400.（中科院二区，IF = 5.1）

[10] Yao Liu, Runzi Zhang, Xiaoyu Yang, Yi He*, Xiao Yang*. Gold nanoparticle-decorated hydrogen-bonded organic frameworks (HOFs@Au) as efficient SERS substrates and photocatalytic tools for ultrasensitive detection and degradation of bisphenol contaminants. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2025, 346, 126890.（中科院二区，IF = 4.6）

[11] Runzi Zhang, Qianyan Zhang, Ying Gao, Jia Yang, Xue Zeng, Minghang Jiang, Mengjun Wang, Xiaojun Luo*, Yi He*. DNAzyme amplifaction strategy coupled with peanut-shaped FexOy @MMC@Au and COF@Au synergistic SERS enhancement for ultrasensitive analysis of chloramphenicol. Sensors and Actuators: B. Chemical, 2024, 401, 134962.（中科院一区，IF = 7.7）

[12] Runzi Zhang, Qianyan Zhang, Jia Yang, Shuping Yu, Xiao Yang*, Xiaojun Luo*, Yi He*. Ultrasensitive detection strategy for CAP by molecularity imprinted SERS sensor based on multiple synergistic enhancement of SiO₂@AuAg with MOFs@Au signal carrier. Food Chemistry, 2024, 445, 138717.（中科院一区，IF = 9.8）

[13] Jia Yang, Runzi Zhang, Jiaxian Liu, Renbo Xiong, Yi He*, Xiaojun Luo*, Xiao Yang*. Well-ordered Au@Ag NBPs/SiO2 nanoarray for sensitive detection of chloramphenicol via DNAzyme-assisted SERS sensing. Food Chemistry, 2024, 454, 139806.（中科院一区，IF = 9.8）

[14] Yi He*, Chenfeng Xie, Qianyan Zhang, Rui Cheng, Xiyu Liu, Yunli Guo, Chunhong Liu, Minghang Jiang, Mengjun Wang*, Xiaojun Luo*. SERS Immunoassay Based on an Enzyme-Catalyzed Cascade Reaction and Metal–Organic Framework/Alkaline Phosphatase for Ultrasensitive Detection of Adenosine Triphosphate. ACS Applied Materials & Interfaces, 2024, 16, 1712–1718.（中科院二区，IF = 8.2）

[15] Runzi Zhang, Shunbi Xie*, Xiang He, Ying Gao, Mengjun Wang, Minghang Jiang, Xiaojun Luo, Yi He*. Ultrasensitive Detection of Chloramphenicol in Milk Using a “Y-Shaped” SERS Biosensor Based on Magnetic Plasmonic Nanostructures and EXPAR Technology. ACS Applied Nano Materials, 2024, 7, 24172−24180.（中科院二区，IF = 5.5）

[16] Runzi Zhang, Shunbi Xie*, Qianyan Zhang, Ying Gao, Xiang He, Shanshan Jin, Junhao Leng, lian Zhang, Yi He*. Explosive CaCO3 microcapsules driven by EDTA combined with a signal booster semiconductor Zn0.995Ce0.005O SERS substrate for ultra-sensitive SERS detection of chloramphenicol. Analytica Chimica Acta, 2024, 1331, 343308.（中科院二区，IF = 6.0）

[17] Runzi Zhang, Shunbi Xie*, Hongcheng Zhang, Jia Yang, Minghang Jiang*, Lian Zhang, Yi He*. A dual-mode colorimetric and surface-enhanced Raman strategy for chloramphenicol detection based on the Au@Pt nanozyme and EXPAR. Microchemical Journal, 2024, 207, 111990.（中科院二区，IF = 5.1）

[18] Zhiyou Zeng, Xiaoyu Yang, Yongguo Cao, Sanshan Pu, Xinyu Zhou, Rongli Gu, Yiqian Zhang, Caijun Wu, Xiaojun Luo and Yi He*. High-efficiency SERS platform based on 3D porous PPDA@Au NPs as a substrate for the detection of pesticides on vegetables. Analytical Methods, 2023, 37, 9.（中科院三区，IF = 2.7）

[19] Yi He*, Xiangjian Liao, Haonan Wu, Jialiang Huang, Yi Zhang, Yanyu Peng, Zhen Wang, Xin cao, Caijun Wu*, Xiaojun Luo*. A controllable SERS biosensor for ultrasensitive detection of miRNAs based on porous MOFs and subject-object recognition ability. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2023, 289, 122134.（中科院二区，IF = 4.6）

[20] Yi He*, Zhiyou Zeng, Yongguo Cao, Xiao Zhang, Caijun Wu*, Xiaojun Luo*. Ultrasensitive SERS biosensor based on Zn2+ from ZnO nanoparticle assisted DNA enzyme amplification for detection of miRNA. Analytica Chimica Acta, 2022, 1228, 340340.（中科院二区，IF = 6.0）

承担本科生分析化学、分析化学实验等教学工作。